8th Clinical Dermatology Congress August 24-25, 2016 Sao Paulo, Brazil

Biography:

Ricardo Hsieh was graduated from the Department of Dermatology, Medical School of University of Sao Paulo and obtained his Master’s and PhD degree. He is currently a Post-doctoral fellow at Department of Pathology, Dental School and Associate Research Scientist at Institute of Tropical Medicine.

Abstract:

Head and Neck Mucosal Melanoma (HNMM) is rare, accounting 1% of all melanomas in the USA and 6% in Japan. It is known that receptor tyrosine kinase (RTK) signaling mediates the development and progression of melanoma; its development is a complex process involving activation of proto-oncogenes and loss of tumor suppressors. The MERTK, AXL and TYRO3 functionally engage in cooperative or distinct signaling cascade and there is evidence that they play a key role in melanoma pathogenesis. C-kit plays a key role in melanocytic development, migration and proliferation; its mutations seem to be more common in mucosal and acral melanomas. Moreover, Bcl-2 oncogene encodes a family of anti-apoptotic proteins and it is overexpressed in melanomas, proto-oncogene C-myc is a transcriptional factor and plays crucial role both in driving cell proliferation and promoting apoptosis, its overexpression has been associated to melanoma progression and oncogene SOX10 cooperates with other transcription factors to direct the development and differentiation of melanocytes. These three nuclear markers are associated to melanoma’s metastatic risk. We studied MERTK, AXL, TYRO3, BCL-2, C-myc and SOX10 in 29 FFPE Head and Neck cases organized in TMA by Alkalin Phosphatase Immunohistochemistry technique. We observed positive expression in: 4/29 MERTK, 29/29 AXL and TYRO3, 15/29 CKIT, 27/29 Bcl-2, 28/29 SOX10, 16/29 C-myc. According to our results, loss of MERTK and CKIT proteins expression seems to play an important role in the HNMM pathogenesis and BCL-2 and SOX10 should be good adjunctive biomarkers for HNMM, further molecular biology studies should corroborate this present study.

Biography:

Amir Feily is dermatologist and researcher in Skin and Stem Cell research Center of Tehran University of Medical Sciences, Tehran and Department of Dermatology of Jahrom University of Medical Sciences, Jahrom, Iran. He is the member of International Society of Dematology , European Academy of Dermatology, Editorial Board of Journal Dermatology Report, Journal of Pigmentary disorder, Aperito Journal of Dermatology , Journal of Drug Metabolism and Toxicology, International Journal of Dermatology Research and Therapy and  Associated editor of Asian Journal of Dermatology. He is also the reviewer of many dermatologic journals such as British Journal of Dermatology (BJD), International Journal of Dermatology (IJD),Clinical Experimental dermatology(CED), Journal of European Academy of Dermatology (JEADV) and etc. He has More than 74 high quality papers in Dermatology and Pharmacology. His recent two awards were 2013 Global Education Award, granted by International Society of Dermatology (IJD) and Imrich Sarkani Non-European Memorial award Granted By European Academy of Dermatology at 23^rd EADV Congress Amsterdam, the Netherland 2014.

Abstract:

Background: Fractional CO2 laser has been reported to be effective in the treatment of refractory and stable vitiligo.

Objectives: Our purpose was to evaluate the effect of the fractional CO2 laser followed by follicular isolation hair transplantation in the treatment of refractory and stable vitiligo and comparing it with hair transplant alone.

Methods: A total of 20 patients with refractory and stable vitiligo presenting at our clinic were enrolled in this randomized prospective half lesion comparative study. Several resistant patches were selected in every patient and randomly divided to two parts and just one part (Part A) was treated with one session fractional CO2 laser. After 5 days equal number of black graft were harvested from scalp and transplanted in both parts. After 5 days dressing the recipient areas were exposed to NBUVB phototherapy twice a week for 3 months. The diameter of repigmentation around each graft was measured monthly by caliper.

Results: After 3 months of examination perifollicular repigmentation was detectable surrounding the 74% of grafted hair follicles. At the end of the first, second and third months of examination the diameter of perifollicular repigmentation of part A was more than part B with 2.96 ± 0.7 mm relative to 2.51 ± 0.6 mm in the first month, 5.36 ± 4.6 mm relative to 3.59 ± 1 mm in the second month and 6.6 ± 5.8 mm relative to 4.3 ±1.8 mm in the third month. There was statistically significant difference between the two groups after all three months of examination.

Conclusion: This study suggests that fractional CO2 laser therapy followed by hair transplant alongside NBUVB photo therapy could be used effectively as an alternative modality for the treatment of refractory vitiligo. Despite promising results, additional studies are required to confirm our study.

Biography:

Ercan Arca was graduated from Gulhane Medical Academy, Faculty of Medicine in 1990. He has completed his Residency during 1993-1996 at Department of Dermatology. He has been working in GMMA, School of Medicine, Department of Dermatology since 2000. He is currently a Professor practicing in the same department. He is interested in psoriasis, biologic agents, pediatric dermatology, cutaneous surgery, laser and cosmetic surgery such as chemical peelings, laser epilation, botox, fillers, facial rejuvenation, dermoscopy, dermatopathology, cutaneous lymphoma. He has published more than 100 papers in reputed journals and also presented 200 oral and poster presentation in both national and international congresses.

Abstract:

Basal cell carcinoma (BCC) is the most common of all cutaneous malignancy. It is locally invasive and often grows slowly. Dermoscopy is a non-invasive, in vivo technique that greatly enhances the clinical diagnostic accuracy in pigmented and non-pigmented skin lesions. Up-to date, dermoscopy has been shown to increase BCC diagnosis by enhancing the differentiation from other skin tumors and inflammatory skin diseases. Classical dermoscopy algorithm for the diagnosis of BCC, especially for the pigmented variant, includes the absence of pigmented network and the presence of at least one of the following criteria: Multiple blue/gray ovoid nests, spoke-wheel structures, arborizing vessels and ulceration. However, BCC may reveal a large variety of dermoscopic features. These non-classical features include some additional criteria more frequently seen in superficial BCC or Fibroepithelioma of Pinkus such as short-fine superficial telangiectasia, concentric structures, multiple small erosions, multiple in focus blue/gray dots, shiny white-red structure less areas. Some dermoscopic structures also present are just visible with polarized non-contact dermoscopy like shiny-white lines (chrysalis) and rosetas. In this presentation, a summary of the dermoscopic features of different types of BCCs and also the value of dermoscopy for diagnosis and management of BCCs will be discussed.

Biography:

Mustafa Turhan Sahin has completed his Medical Education from Erciyes University Medical Faculty, Turkey in 1989. His Dermatology Residency was in Dokuz Eylül University Medical Faculty, Turkey. He is currently working as a Professor in the Celal Bayar University, Medical Faculty Department of Dermatology, Turkey. Many of his studies and case reports were published in national and international journals. He is a Member of Dermatovenereology Association of Turkey, Turkish Dermatology Association, Turkish Dermatopathology Association, Turkish Skin and Venereologic Diseases Association, International Society of Dermatology (ISD), European Academy of Dermatology and Venereology (EADV), American Academy of Dermatology (AAD) (Since 2001) and also a Board Member in International Dermoscopy Society (IDS).

Abstract:

Targetoid hemosiderotic hemangioma, also known as hobnail haemangioma, is benign, solitary, targetoid vascular neoplasm occurring predominantly on the proximal extremities and trunk. Most patients exhibit a typical, targetoid haemangioma, whereby a small, solitary, purple and/or brown papule is surrounded by an ecchymotic ring that can expand or subsequently disappear with persistence of the central papule. The halo, however, is not a constant finding, thus the term hobnail haemangioma was coined to describe the non-targetoid variant of targetoid hemosiderotic haemangioma. Duration of the lesions ranges from 1 month to 20 years. During this time, targetoid hemosiderotic haemangioma may undergo episodic and cyclic changes in morphology. Dermoscopy has been scarcely used in the diagnosis of targetoid hemosiderotic haemangioma. Here we describe our cases of targetoid hemosiderotic haemangioma and study their monthly changing dermoscopical findings to show that this technique could be useful in the monitoring and differential diagnosis of this scarcely reported entity.

Biography:

Camila Folle was graduated in Pharmaceutical Science from London Metropolitan University in 2011 and has completed Masters degree in Cosmetics & Dermopharmacy by CESIF Barcelona, including a year Internship at ISDIN S.A., and recently completed second Master’s degree in Nanoscience & Nanotechnology (2015) from the University of Barcelona. Presently, she is researching dermatological active ingredients applied nanotechnology.

Abstract:

Antimicrobial nanotechnology show promising activity for topical delivery on dermatologic acne treatment due to its potential of being mainly retained in the deeper layers of the skin, where acne develops. The acne evolution occurs by excessive sebum production at the hair follicle proximities, which leads to Propionibacterium acnes proliferation and a resulting inflammation. It is relevant that nanotechnology has several advantages such as, small particle diameter to penetrate inside skin tissues, sustained drug withdrawn and lower doses required for its efficacy. Moreover, the skin fat tissues are likely to behave as a deep hosting compartment for the nanoparticles. This research relies primarily on optimization and characterization of the desired formulation, then determining the efficacy of the drug nanosystem against P. acne by its minimal inhibitory concentration (MIC). Thus, in vitro release profiles of the drug nanoparticles and the free drug are compared under kinetic models, determining its biopharmaceutical transmembrane behavior using Franz diffusion cell. The skin permeability parameters are studied in ex vivo models, determining the amounts of drug retained inside the skin, using skin extraction and tape stripping techniques. P. acnes is also hosted by deep skin tissues, therefore, the amount of drug found retained in the deeper layers of the skin is then calculated towards the MIC value of the antimicrobial agent and further classified its efficiency for acne treatment. Nevertheless, this advanced methodology exempts the use of animal test, being suitable for cosmetic industries.

Biography:

Amir Feily is dermatologist and researcher in Skin and Stem Cell research Center of Tehran University of Medical Sciences, Tehran and Department of Dermatology of Jahrom University of Medical Sciences, Jahrom, Iran. He is the member of International Society of Dematology , European Academy of Dermatology, Editorial Board of Journal Dermatology Report, Journal of Pigmentary disorder , Aperito Journal of Dermatology , Journal of Drug Metabolism and Toxicology, International Journal of Dermatology Research and Therapy and  Associated editor of Asian Journal of Dermatology. He is also the reviewer of many dermatologic journals such as British Journal of Dermatology (BJD), International Journal of Dermatology (IJD),Clinical Experimental dermatology(CED), Journal of European Academy of Dermatology (JEADV) and etc. He has More than 74 high quality papers in Dermatology and Pharmacology. His recent two awards were 2013 Global Education Award, granted by International Society of Dermatology (IJD) and Imrich Sarkani Non-European Memorial award Granted By European Academy of Dermatology at 23^rd EADV Congress Amsterdam, the Netherland 2014.

Abstract:

Hair restoration is a safe procedure and  most of its associated complications are preventable by the surgeon and/or the patient. Recipient area necrosis is rare but arises when an increased number of recipient grafts are utilized and de-vascularization of the scalp occurs. The aim of this study was to investigate and compare all cases and pictures reported in main search engines and Iranian centers of hair transplant to find the dangerous zone of necrosis and to provide a new method for prevention of necrosis. Pictorial analysis of this study revealed that the majority of necrosis (14 of 18) occurs in central region of the scalp and is inclined, particularly, to the right parietal aspect of the scalp. Accord­ingly, a case series was done and a new method for prevention of scalp necrosis even in dense packing transplantation was discussed.

Biography:

Rutao Cui is a Professor, Vice Chair of Pharmacology and Experiment Therapeutics, Professor of Dermatology and Director of Melanoma Biology, Boston University, USA. His studies were regarded as pioneer work in the research community and have been highlighted by various journals including Nature and Science and NIH Director, Dr. Francis Collins in his blog and also have been reported in different news including CBS news.

Abstract:

Variants in the melanocortin-1-receptor (MC1R) gene, encoding a trimeric G protein-coupled receptor activated by α-melanocyte-stimulating hormone (α-MSH) are frequently associated with red or blonde hair, fair skin, freckling and skin sensitivity to ultraviolet (UV) light and several (RHC-variants) also associate with increased melanoma risk. However, not all of these associations have been attributed to phenotype, suggesting that some variants affect melanoma risk independent of phenotype. We have introduced MC1R loss-of-function mutations into the albino mice with complete absence of melanin and found that MC1R loss-of-function mutations augment UV-induced melanoma development in vivo, independent of their effects on pigmentation. For the additional roles of MC1R in melanoma development beyond pigmentation, MC1R controls UVB-induced G1-like cell cycle arrest and subsequent onset of premature senescence in melanocytes, abrogation of which contributes to melanoma development. Mechanistically, wt-MC1R stabilized PTEN against proteolytic degradation under UV exposure, resulting in inhibition of AKT phosphorylation and activation after UV exposure. These results provided a key insight into why red haired people are more likely to get melanoma and will potentially lead to the development of novel strategies and identification of therapeutic targets for melanoma toward developing targeted therapies in preventing and treating red-haired population suffering from melanoma.

Biography:

Laura Maria Andrade Silveira is a Dermatologist and currently a PhD student at Federal University of Bahia. She has specialty training in Trichology and Cosmiatrics from Federal University of São Paulo-UNIFESP and University of São Paulo-USP. She works at Trichology Department in Federal University of Bahia, Dermatology Department of Professor Edgar Santos Medical Complex. She has published some papers in reputed journals and has been serving as paper Reviser. She is a Member of Brazilian Society of Dermatology and Brazilian Society of Dermatology Surgery. She also works at Bahia Hospital in Salvador Bahia, Brazil as a Dermatologic Consultant.

Abstract:

Hair loss is a common and distressing symptom, affecting men and women. Genetic hair loss is the most common. Telogen effluvium, which causes hair shedding is common cause of hair loss, may develop after crash dieting, medication intake, illness and childbirth. Alopecia areata is found in about 1.7% of the population. Most cases start during childhood and present as a chronic disease throughout life. Other causes are associated with hair breakage, can be genetic or related with hair care treatments. The objective of this presentation is to synthetize what is new in diagnosis and treatment of all this conditions as digital trichogram and trichoscopy evaluation, Janus Kinase (JAK) inhibitors and platelet rich plasma. Evaluation of hair shedding was traditionally realized by physical exam, blood tests and trichogram. Recently a new toll was release to dermatology as an improvement of dermatoscopy and trichoscopy. This new method is really useful in diagnosis of almost all hair conditions, genetic disorders and acquired conditions but digital trichogram seems not to be as practical and useful as the trichoscopy. It is an expensive method in comparison of the traditional method and not as sensible as the old one. Inhibitors of the Janus Kinase (JAK) seem to be a new promise treatment for alopecia areata and other hair disorders. Recently it was demonstrated that topical treatment of mouse and human skin with small-molecule inhibitors of the JAK pathway results in rapid onset of anagen and subsequent hair growth. It seems that JAK inhibition regulates the activation of key hair follicle populations. Platelet rich plasma (PRP) is another promise therapy for a genetic hair loss and a lot of other kinds of hair disease. It is being increasingly used in medical treatments around the world. PRP has been used by physicians since the 1990′s in various areas of medicine which seems to help about 50% of men with hair thinning, especial when hair transplantation is not an option but also can be used in alopecia areata and telogen effluvium.

Biography:

Shuba Dharmana is the Founder and CEO of Lejeune group of Medspas, which she presently runs in Bangalore and Hyderabad and is a Consult at various multispecialty hospitals across India. She is a crowned “Woman Entrepreneur of the Year 2012” amongst several other prestigious awards. After graduating from the Andhra Medical College, India, she left for UK where she trained and practiced for 10 years in General Practice and undertook a Post Graduate Diploma in Clinical Dermatology from the University of Cardiffm UK. She discovered her passion in aesthetic medicine and trained under eminent aesthetic physicians, working for several clinics all across UK. She was also trained in hair transplantation techniques in Poland under one of the Europe’s most reputed hair transplant surgeons, Dr. Marwan Saifi.

Abstract:

Acanthosis nigricans is a condition involving symmetrical hyperpigmentation and thickening of the skin in the flexures like neck, axilla and groin. It is strongly associated with insulin resistance, obesity, polycystic ovarian syndrome and some malignancies. It is important to screen people with AN for insulin resistance and advocate lifestyle changes, weight reduction etc to reduce the risk of diabetes and its complications. Whilst underlying causes need to be corrected, lightening of the patches poses a problem. It is often resistant to treatment and recurrence is common. A variety of topical skin lightening agents like hydroquinone, azelaic acid, triple combination cream, chemical peels, keratolytic agents like salicylic acid, emollients, calcipotriol, metformin, octreotide, oral and topical retinoids , CO₂ ablation, long pulsed alexandrite laser are all used to improve appearance.

Biography:

Sushma Yadav has pursued MBBS at Ambedkar Medical College in Bangalore from 2004-2008 and later completed Post graduate degree in Dermatology, Venereology and Leprology (DVL) in Vydehi Medical College in 2012. She has been a Member of few well recognized medical organizations across the state which includes Indian Association of Dermatology, Venereology and Leprology (IADVL), Indian Association for the Study of Sexually Transmitted Diseases, Indian Association of Leprologist and Bangalore Dermatology Society.

Abstract:

Epidermal nevi are hamartomatous proliferation of the epithelium including the keratinocytes, sebocytes, pilosebaceous units, eccrine glands or apocrine glands. Epidermal nevus present with developmental abnormalities of the nervous, cardiovascular, urogenital and skeletal system. Also called as linear verrucous epidermal nevus, they are characterized by localized or diffuse, close-set, skin colored, brown to gray brown verrucous papules, which may coalesce to form well demarcated papillomatous plaques. Variants localized, systematized, nevus uniuslateris, ichthyosishystrix and inflammatory type. Eighty percent of the lesions appear within the first year of life with majority of the lesions appearing by the age of 14. There are rare reports of adult onset of epidermal nevi, therefore presenting a case of epidermal verrucous nevi in a 32 year old male patient with adult onset.

Biography:

Helgi Valdimarsson is a Professor of Immunology at the University of Iceland. He established the first Immunology Laboratory of Iceland in 1983. He was a Senior Lecturer at St Mary's Hospital Medical School, London, England from 1975-1981 and a Visiting Professor at St. Mary’s from 1981-1990. He has published over 180 articles in international peer reviewed journals and for his work on psoriasis he has received several research grants including European Commission Grant (1998-2002) and a Fogarty Scholarship in 2003.

Abstract:

It is now generally accepted that psoriasis is a T-lymphocyte mediated inflammatory disease. Early data supporting this concept, published about 25 years ago, were initially subjected to vigorous and healthy scepticism and discussed as current controversy as late as 2000. However, this paradigm is now generally accepted and management with agents that selectively block certain T-lymphocyte sub-populations is now the treatment of choice for patients with moderate to severe psoriasis. The nature of the antigens involved, remains to be fully established but some recent findings have strongly implicated streptococcal components. Genetic analyses have identified a number of susceptibility alleles that may predispose to psoriasis, including the HLA-Cw6 allele that is carried by about 60% of the patients, compared with only about 15% of population controls. Many other susceptibility alleles with lower penetrance have been identified and some may be associated with defects in innate immunity. Although the innate immune system does not directly involve antigen specific immune mechanisms, it closely interacts in a variety of ways with adaptive immunity. Thus, it is well established that defective innate immunity predisposes to antigen specific autoimmune diseases. HLA-Cw6 positive psoriasis patients respond abnormally to short keratin peptides that share sequences with streptococcal M protein and vice versa. Furthermore, improvement of psoriasis after tonsillectomy correlates closely with decrease in the frequency of circulating CD8 T lymphocytes that recognize such peptides. It is therefore proposed that HLA-Cw6 positive psoriasis patients have molecular mimicry based autoimmunity. Whether other mechanisms operate in HLA-Cw6 negative psoriasis patients remains to be elucidated.

Biography:

Irina Khamaganova has completed her PhD degree from the State Scientific Research Centre for Dermatovenerology. She has completed her Doctoral degree from Russian National Research Medical University, Russia. She is a Professor at the Department of Skin Diseases & Cosmetology at Russian National Research Medical University. She is a Member of the European Society for Dermatological Research and since 2011 she takes part in the annual meetings of ESDR. She has published more than 100 papers in reputed journals.

Abstract:

Rosacea is a common inflammatory facial skin disease, characterized by erythema, telangiectasia, papules and pustules. Perioral dermatitis is a common inflammatory facial skin disorder as well. A typical perioral dermatitis presentation involves the eruption of papules and pustules that may recur over weeks to months, occasionally with fine scales. The differential diagnosis includes rosacea besides other diseases. The dysregulation of the innate immune system may have a role in promoting the clinical features of rosacea & perioral dermatitis. The objective of this study was the complex analysis of innate immunity of the keratinocytes in patients with rosacea & perioral dermatitis. Materials & methods: 35 patients with rosacea & 5 patients with perioral dermatitis were examined. Total RNA was isolated from keratinocytes RNA was combined with random and reverse primers for the target genes for cDNA synthesis .The real-time PCR was performed for quantitative analysis. The median of the expression of TLR2 was significantly reduced both in the affected skin to 3856 and in healthy skin in rosacea patients to 2627 in comparison with 34191 in patients with perioral dermatitis. The median of the expression of hBD1 was significantly raised both in the affected skin to 28318 and in healthy skin in rosacea patients to 24732 in rosacea patients in comparison with 7415. The median of the expression of hBD2 was significantly reduced both in the affected skin to 2267 and in healthy skin in rosacea patients to 1990 in comparison with 5553. The investigation showed statistically significant difference of the indicators of innate immunity in patients with rosacea & perioral dermatitis.