10th International Conference on Dermatology & Cosmetology
Chicago, USA
Yun Ho Lee
Department of Dermatology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 29, Saemunan-ro, Jongno-gu, Seoul, Korea
Title: Development of Generalized Pustular Psoriasis-like Eruptions and Alopecia Areata after Biologic Therapy in a Psoriasis Patient
Biography
Biography: Yun Ho Lee
Abstract
Psoriasis is an immune mediated chronic skin disease that afflicts the patient physically and emotionally. Currently there are many targeted drugs including tumor necrosis factor (TNF) inhibitors, T-cell inhibitors and interleukin (IL)-12/IL-23 inhibitors as effective substitutes for conventional systemic treatments. Although these drugs was proved to be relatively safe, various side effects have been reported.
A 46-year-old female had a long-standing history of psoriasis that was inadequately controlled by phototherapy, systemic and topical treatment. Adalimumab (Humira®) was applied 5 times during two months. One week after fifth injection of adalimumab, her psoriatic lesions were aggravated and numerous scattered erythematous pustules were observed on whole body. Adalimumab was applied 4 times more, but there was no improvement, so she had received ustekinumab (Stelara®). Two weeks after administarion of ustekimumab, the patient presented with 3 alopecic patches on scalp. Trichoscopy of the affected area showed vellus hair and yellow dot. The patient continued to be treated with ustekinumab (Stelara®) and applied a topical 0.05% clobetasol-17-propionate (Dermovate® solution) for alopecia areata treatment, then she experienced improvement of psoriatic lesions and hair regrowth. We report this patient as a case of rare side effects following treatment with biologic agents.
Keywords: Adalimumab, Alopecia areata, Generalized Pustular Psoriasis, Ustekinumab